Bio
Adriano Rutz is a pharmacist. After working in the analytical research laboratory and R&D department of Tradall SA (Bacardi Group), he obtained his PhD in phytochemistry at the University of Geneva. An advocate of open science and open data, he is the proud author of the LOTUS initiative, a new way of sharing knowledge in natural products research. He is currently developing open computational tools and mass spectrometry-based strategies to better understand the chemistry of living organisms.
Experience
Postdoctoral Researcher, ETH Zürich (2022 - present)
Computational metabolomics at the Institute of Molecular Systems Biology.
Research & Teaching Assistant, UNIGE (2017 - 2022)
Development of LC-HRMS/MS based approaches for comprehensive composition assessment of complex plant extracts.
In depth annotation using Spectral Networking. Plant metabolomics.
Teaching activities with Bachelor and Master students.
Maintenance and optimization of analytical instruments (LC).
Junior Research Chemist, Tradall (2016 - 2017)
Working in analytical research and Research & Development laboratories following ISO norms.
New products development, analytical and sensory characterization.
In depth analysis of impact compounds, compounds evolution understanding.
Maintenance and optimization of analytical instruments (GC).
Assistant Pharmacist, Pharmacie de la Terrassière (2015 - 2016)
Internship in the frame of Master’s degree.
Education
Ph.D. in Pharmaceutical Sciences, UNIGE (2017 - 2022)
Thesis entitled « Integrative Analytical and Computational Strategies for Qualitative and Semi-quantitative Plant Metabolome Characterization »
B.Sc. and M.Sc. in Pharmaceutical Sciences, UNIGE (2011 - 2016)
Mention « excellent » for Master’s thesis « GC chiral separation of main enantiomeric compounds as a tool of Quality Control of some botanicals and related specific final product »
Skills
- Mass Spectrometry based annotation and dereplication
- Metabolomics
- Natural Products chemistry (extraction, isolation, characterization)
- Programmatic data treatment, ease with progamming (different languages)
- Data oriented, knowledge management
- Sensory analysis
Leadership
Scientific contribution
-
Automated Composition Assessment of Natural Extracts: Untargeted Mass Spectrometry-Based Metabolite Profiling Integrating Semiquantitative Detection Permalink
Rutz, A., Wolfender, J. L. (2023). Automated Composition Assessment of Natural Extracts: Untargeted Mass Spectrometry-Based Metabolite Profiling Integrating Semiquantitative Detection. Journal of Agricultural and Food Chemistry, 71 (46), 18010. https://doi.org/10.1021/acs.jafc.3c03099
-
The LOTUS initiative for open knowledge management in natural products research Permalink
Rutz, A., Sorokina, M., Galgonek, J., Mietchen, D., Willighagen, E., Gaudry, A., Graham, J. G., Stephan, R., Page, R., Vondrášek, J., Steinbeck, C., Pauli, G. F., Wolfender, J. L., Bisson, J., & Allard, P. M. (2022). The LOTUS initiative for open knowledge management in natural products research. eLife, 11, e70780. https://doi.org/10.7554/eLife.70780
-
Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation Permalink
Rutz, A., Dounoue-Kubo, M., Ollivier, S., Bisson, J., Bagheri, M., Saesong, T., Ebrahimi, S. N., Ingkaninan, K., Wolfender, J. L., & Allard, P. M. (2019). Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation. Frontiers in plant science, 10, 1329. https://doi.org/10.3389/fpls.2019.01329
Advocacy
-
Introduction to Linked Open Data for Computational Mass Spectrometry
Talk at Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic
-
Lotus: A Living Knowledge Base for Modern Pharmacognosy
Talk at University of Innsbruck, Institute of Pharmacy, Innsbruck, Austria
-
Prior knowledge as a compass guiding untargeted metabolomics
Poster at Swiss Metabolomics Society Annual Meeting, Zürich, Switzerland
-
Deep metabolome annotation
Plenary and interactive lecture at 6e Symposium International de l'AFERP, Saclay, France
-
A Distillate of the LOTUS Initiative in Natural Products Research: Sharing Information, Building Knowledge, Extracting Wisdom
Talk at 71th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Dublin, Ireland
-
Metabolomics Workshop
Plenary and interactive lecture at Summer School on Applied Meta-Omics, Zürich, Switzerland
-
Prior knowledge as a compass guiding untargeted metabolomics
Talk at Jena Centre for Bioinformatics, Jena, Germany
-
The LOTUS Initiative: Integrating Natural Products to the Wikidata Knowledge Base
Poster at LS2 Annual Meeting 2022 - Life Sciences in the 2020s: Quantitation, Integration and Prediction, Zürich, Switzerland
-
The LOTUS Initiative: Integrating Natural Products to the Wikidata Knowledge Base
Talk at LS2 Annual Meeting 2022 - Life Sciences in the 2020s: Quantitation, Integration and Prediction, Zürich, Switzerland
-
The LOTUS Initiative for Open Natural Products Research: Knowledge Management through Wikidata
Talk at i-npchem inaugural e-meeting,
-
Untargeted chemical and sensory characterization of Swertia chirayita: a bitter case study
Poster at 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research,
-
The LOTUS initiative for knowledge sharing in Natural Products research
Talk at 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research,
-
LOTUS, a Wikidata hosted open naturaL prOducTs occUrrences databaSe
Talk at 2nd RFMF Junior Webinar Series,
-
Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation
Talk at 1st GNPS user meeting,
-
Advanced Course on Mass Spectrometry
Plenary and interactive lecture at Università degli Studi di Napoli Federico II, Pharmaceutical Sciences, Napoli, Italy
-
Strategy for exhaustive plant metabolomes characterization from a qualitative and quantitative perspective
Poster at 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Innsbruck, Austria
-
Development of a Generic Method for a Comprehensive Composition Assessment for Plants of Industrial Interest – Quali/quantitative profiling by UHPLC-PDA-HRMS-ELSD
Talk at Second Austrian Summit on Natural Products, Seefeld, Austria